On a margin account (using borrowed money to trade with) on some exchanges, you might see the options for Cross and Isolated Margin. If you choose Isolated Margin when entering a trade, that means that you want the only the margin used for that trade to support it. The rest of your account will not act as collateral for the margin trade.

Say you have $10,000 in your account, and the price of bitcoin is $10,000. You go long $1,000 on bitcoin with 10x leverage, meaning you open a position of $10,000 or 1 bitcoin. With Isolated Margin, your position would close when the price of bitcoin dropped 10% (10% * 10 = 100%) ato $9,000 and you'd lose all $1,000—even if the price then bounced up to $11,000.

Isolated Margin protects the rest of your account in case the price moves against you. At worst, you'll hit a margin call and lose 100% of the margin put up for the trade—without risking the rest of your account.